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Hypermethioninemia can come about with other metabolic Issues, like homocystinuria, tyrosinemia, and galactosemia, which also require the faulty breakdown of unique molecules. It can also consequence from liver disease or too much dietary ingestion of methionine from consuming big amounts of protein or simply a methionine-enriched toddler components.
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A typical neurological attribute of the disorder is impaired myelin manufacturing (dysmyelination). Myelin is a fatty compound that insulates nerve cells and encourages the swift transmission of nerve impulses.
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The impacted bones might on their own be distressing, or agony could be because of arthritis in nearby joints. Arthritis benefits once the distortion of bones, specially pounds-bearing bones within the legs, leads to extra wear and tear to the joints. Arthritis most often has an effect on the knees and hips in individuals with this disorder.
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Mothers of youngsters with trichothiodystrophy may possibly working experience challenges during pregnancy together with pregnancy-induced superior blood pressure level (preeclampsia) as well as a connected problem called HELLP syndrome that can damage the liver.